Cytotoxic Effects of Kirinyuh Herb (Austroeupatorium inulaefolium (Kunth) R. d. King & H. Robinson) Extracts and Fractions on BSLT, MCF-7 Cells and T-47D Cells
نویسندگان
چکیده
Breast Cancer is the second-highest prevalence of cancer disease in Indonesia, with number new cases and deaths continues to increase. Kirinyuh or Austroeupatorium inulaefolium (Kunth) R. D. King & H. Robinson a shrub plant, which are widely grown Indonesia. Traditionally, it used for woundhealing information about anticancer potential A. still very limited. This study aims assess cytotoxic activity on MCF-7 T-47D breast cells. Tests that carried out this were phytochemicals screening, Brine Shrimp Lethality Test (BSLT) Cytotoxicity assay. The screening showed EA (leaves extracts levels 1-3), EB 4-6) EC (stalk extracts) contained tannin, steroids/triterpenoids, flavonoids phenols. BSLT results has smallest LC50 value 12.86 μg/mL. MTT assay IC50 extract fraction cells 204.96 μg/ mL FEA 205.43 μg/mL 217.03 192.36 conclusion toxicity cytotoxicity herb stalks) ethanol 96% had toxic effect however less
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ژورنال
عنوان ژورنال: Pharmacognosy Journal
سال: 2022
ISSN: ['0975-3575']
DOI: https://doi.org/10.5530/pj.2022.14.48